GW 6471

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW6471 是一种 PPARα 拮抗剂，IC50 为 0.24 μM。GW6471 增强 PPAR α 配体结合结构域与共阻遏蛋白 SMRT 和 NCoR 的结合亲和力。一种特异性 PPARα 拮抗剂。

GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4;?this data was confirmed as specific to PPARα antagonism by siRNA methods.

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Metabolic Enzyme/Protease

PPAR

PPARα

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880635-03-0

619.67

C35H36F3N3O4

>98% (HPLC)

DMSO:120 mg/mL (193.65 mM; Need ultrasonic)

CCC(NC[C@@H](N/C(C)=C\C(C1=CC=C(C(F)(F)F)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2)=O

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(-20℃)

With Ice Pack

≥ 2 years